World number one Serena Williams saw her winning streak and hopes of a sixth Wimbledon title end with a shock defeat by Germany's Sabine Lisicki.
Lisicki, the 23rd seed, won the fourth-round encounter 6-2 1-6 6-4 on Centre Court.
Williams joins leading names Maria Sharapova, Victoria Azarenka, Roger Federer and Rafael Nadal in making an early exit at what has been a tournament of stunning upsets.
It was only the third defeat in the last year for Williams, and ends her career-best winning run of 34 matches.
Lisicki moves on to the quarter-finals for the fourth time and in each of those Wimbledon campaigns she has beaten the French Open champion.

Match stats

WilliamsLisicki
Match time: 2 hrs 04mins
7
Aces
10
2
Double faults
3
62%
1st serve %
61%
58%
1st serve win %
57%
50%
2nd serve win %
47%
25
Winners
35
23
Errors
25
5/16
Break points
5/8
Her record on grass, based around the second-biggest serve in women's tennis, meant Lisicki had always looked among the most likely candidates to challenge Williams.
The 23-year-old from Troisdorf fought off four break points and took advantage of a rash of Williams unforced errors as she broke twice to win the opening set.
Williams, 31, was not about to go quietly and roared back in the second, winning 14 points in a row at one stage and not making a single unforced error as she levelled, winning it 6-1.
The American was on a roll and did not need any luck but from 40-0 down, two net cords helped her to an early break in the decider.
When Williams racked up her ninth straight game to move 3-0 clear, it was turning into a procession, but Lisicki stuck to her task.
The German got the better of three breaks in a row as she fought back from 4-2 down, thrilling the 15,000 spectators on Centre Court.
Williams had been in the ascendancy for well over an hour, but at 4-4 in the final set she found herself facing break points and, stretched to the limit, the champion could not control a smash, which flew over the baseline.
"Lisicki played fearless tennis. She was so resilient. I was so impressed with the way she was able to elevate her game to a new level. It was an absolutely amazing performance."
One more service game was required by Lisicki, and it was never likely to be straightforward.
After being pegged back to 30-30, she blasted long on her first match point and double-faulted to offer up a break point for Williams, but the German's serve came to her rescue.
When a second chance to clinch the win of her life arrived, Lisicki played a fearless rally, pounding away from the baseline until Williams could no longer cover the gaps and had to watch as a forehand flew past her.